Chemistry

CHEMISTRY and BIOCHEMISTRY

Recent Publications by Faculty and Students (2008 to present)


Interim Dean, Dr. David Horgen

F. David Horgen, Ph.D. (dhorgen@hpu.edu)
Professor of Chemistry
Interim Dean, College of Natural and Computational
(joined HPU Spring 2000)


TRPM7 triggers Ca2+ sparks and invadosome formation in neuroblastoma cells.
D Visser, M Langeslag, KM Kedziora, J Klarenbeek, A Kamermans, FD Horgen, A Fleig, FN van Leeuwen, K Jalink
Cell Calcium, 54, 404−415 (2013)

Cytotoxic Alkaloids from the Whole Plants of Zephyranthes candida
Zengwei Luo, Fuqian Wang, Jinwen Zhang, Xingyao Li, Mengke Zhang, Xincai Hao, Yongbo Xue, Yan Li, F. David Horgen, Guangmin Yao, and Yonghui Zhang
Journal of Natural Products, 75, 2113−2120 (2012)

Waixenicin A inhibits cell proliferation through magnesium-dependent block of transient receptor potential melastatin 7 (TRPM7) channels.
S Zierler, G Yao, Z Zhang, CW Kuo*, P Pörzgen, R Penner, FD Horgen, A Fleig
Journal of Biological Chemistry, 286, 39328-39335 (2011)
Featured on issue 45 cover
*HPU undergraduate student

Development and optimization of a high-throughput bioassay for TRPM7 ion channel inhibitors.
B Castillo*, P Porzgen, R Penner, FD Horgen, A Fleig
Journal of Biomolecular Screening, 15, 498-507 (2010)
*HPU graduate student

Halogenated fatty acid amides and cyclic depsipeptides from an eastern Caribbean collection of the cyanobacterium Lyngbya majuscula.
JI Jiménez, T Vansach*, WY Yoshida, B Sakamoto, P Pörzgen, FD Horgen
Journal of Natural Products, 72, 1573-1578 (2009) PMC3510382 (PubMed Central full text)
*HPU undergraduate student

Isolation and Structure determination of malevamide E, a new dolastatin 14 analogue, from the marine cyanobacterium Symploca laete-viridis.
B Adams*, P Pörzgen, WY Yoshida, HE Westenburg, FD Horgen
Journal of Natural Products, 71, 750-754 (2008)
*HPU undergraduate student

Determination of microbial community structures of shrimp floc cultures by biomarkers and analysis of floc amino acid profiles.
ZY Ju, I Forster, L Conquest, W Dominy, WC Kuo*, FD Horgen
Aquaculture Research, 39,118-133 (2008)
*HPU undergraduate student

Dr. Fang

Jiasong Fang, Ph.D. (jfang@hpu.edu)
Professor of Chemistry
(joined HPU in 2008)


Magnetovibrio blakemorei, gen. nov. sp. nov., a new magnetotactic bacterium (Alphaproteobacteria: Rhodospirillaceae) isolated from a salt marsh. DA Bazylinski, TJ Williams, CT Lefèvre, D Trubitsyn, J Fang, TJ Beveridge, BM Moskowitz, B Ward, S Schübbe, BL Dubbels, B Simpson
 International Journal of Systematic and Evolutionary Microbiology (2012)

Microbial diversity and biomineralization in low-temperature hydrothermal iron–silica-rich precipitates of the Lau Basin hydrothermal field.
J Li, H Zhou, X Peng, Z Wu, S Chen, J Fang
FEMS Microbiology Ecology, 81, 205–216 (2012)

Biosynthesis of sterols and wax esters by Euglena of acid mine drainage biofilms: implications for eukaryotic evolution and the early earth.
S Dasgupta, J Fang, SS Brake, SS Hasiotis, L Zhang
Chemical Geology, 306–307, 139–145 (2012)

Driving mechanisms for the DOC increases in surface waters released from Northern Peatlands under global change.
X Wu, J Fang, MO Xiang, HE Ling, S Xin-Ting
Earth Science Frontiers, 18, 72–78 (2011)

Assessing the severity of rainfall derived infiltration and inflow and sewer deterioration based on the flux stability of sewage markers.
JM Shelton, L Kim, J Fang, C Ray, T Yan, T
Environmental Science and Technology, 45, 8683–8690 (2011)

Piezophilic bacteria.
J Fang, L Zhang,
The Encyclopedia of Geobiology, Springer Encyclopedia of Earth Sciences Series (2011)

Genomics, metagenomics, and microbial oceanography—a sea of opportunities.
J Fang,  L Zhang
Science China (Earth Sciences), 54, 473–480 (2011)

Explore the deep biosphere. J Fang, L Zhang
Science China (Earth Sciences), 54, 1–9 (2010)

The deep-sea piezosphere and piezophiles: geomicrobiology and biogeochemistry.
J Fang, L Zhang, DA Bazylinski
Trends in Microbiology, 18, 413-422 (2010)

Deep-sea piezophilic bacteria: geomicrobiology and biotechnology.
J Fang, C Kato
Geomicrobiology: Biodiversity and Biotechnology, ISBN 978-1-57808-665-8 (2010)

Deep-sea geomicrobiology.
J Fang, DA Bazylinski
High-Pressure Microbiology, 237-264 (2008)

Deep-sea piezophilic bacteria, ocean carbon cycle, and climate change.
J Fang, C Kato
The Encyclopedia of Global Warming and Climate Change, 2, 557-558 (2008)


Dr. Chen

Yongli Chen, Ph.D. (ychen@hpu.edu)
Associate Professor of Chemistry
Program Chair, Physical Sciences
(joined HPU in 2007)


A new accurate quadratic equation model for isothermal gas chromatography and its comparison with the linear model.  
L Wu, M Chen, Y Chen, QX Li
Journal of Chromatography A, 1260, 224-231 (2012)

Difference equation model for isothermal gas chromatography expresses retention behavior of homologues of n-alkanes excluding the influence of holdup time.  
L Wu, Y Chen, SAL, Caccamise, QX Li
Journal of Chromatography A, 1260, 215-223 (2012)

Caged neurotransmitters and other caged compounds: design and application.
GP Hess,  RW Lewis, Y Chen
In Imaging Neurons: A Laboratory Manual, ISBN 978-0-879699-36-9 (2010) 


Dr. Berger

Gideon Berger, Ph.D. (gberger@hpu.edu)
Assistant Professor of Chemistry
(joined HPU in 2010)


A flexible method for the conjugation of aminooxy ligands to pre-formed complexes of nucleic acids and lipids.
JG Hecker, GO Berger, KA Scarfo, S Zou, MH Nantz
ChemMedChem, 3, 1356-1361 (2008)


Dr. Wang

Lei Wang, Ph.D. (lwang@hpu.edu)
Assistant Professor of Chemistry
(joined HPU in 2012)

Reining in Polyoma Virus Associated Nephropathy: Design and Characterization of a Template Mimicking BK Viral Coat Protein Cellular Binding.
CO Audu, B O'Hara, M Pellegrini, L Wang, WJ Atwood, DF Mierke
Biochemistry, Epub ahead of print (2012)

 Structural Studies of Amyloids by Quenched Hydrogen–Deuterium Exchange by NMR.
M Vilar, L Wang, R Riek
Amyloid Proteins: Methods and Protocols, ISBN 978-1-61779-551-0 (2012)

Structural and Toxic Properties of Protein Aggregates: Towards a Molecular Understanding of Alzheimer's Disease
L Wang, S Campioni
Alzheimer's Disease Pathogenesis, ISBN 978-953-307-690-4 (2011)

Multidimensional structure–activity relationship of a protein in its aggregated states.
L Wang, D Schubert, MR Sawaya, D Eisenberg, R Riek
Angewandte Chemie International Edition, 122, 3996-4000 (2010)

Transnitrosylation of XIAP regulates caspase-dependent neuronal cell death.
T Nakamura, L Wang, CCL Wong, FL Scott, BP Eckelman, X Han, C Tzitzilonis, F Meng, ZZGu, EA Holland, AT Clemente, S Okamoto, GS Salvesen, R Riek, JR Yates III, SA Lipton
Molecular Cell, 39,184-195 (2010)

Structure-activity relationship of amyloid fibrils.
SK Maji, L Wang, J Greenwald, R Riek
FEBS Letters, 583, 2610-2617 (2009)

Solid‐State NMR Spectroscopy Reveals that E. coli Inclusion Bodies of HET‐s (218–289) are Amyloids.
C Wasmer, L Benkemoun, R Sabaté, MO Steinmetz, B Coulary, L Wang, R Riek, SJ Saupe, BH Meier
Angewandte Chemie International Edition, 48, 4858-4860 (2009)

Towards revealing the structure of bacterial inclusion bodies.
L Wang
Prion, 3, 139 (2009)

Bacterial inclusion bodies contain amyloid-like structure.
L Wang, SK Maji, MR Sawaya, D Eisenberg, R Riek
PLoS Biology, 6, e195 (2008)